New Products  New Products Cognagen DeFlame Nutrition Pack Lunora Probiotic 20 Plus Red Yeast Rice Ubiquinol Prime

Nutritional Foundation Products  Nutritional Foundation Products AVED-Multi® DeFlame Nutrition Pack Magnesium - Clinical Magnesium Omega-3 - Clinical Omega-3 Ultra K2-D3 Essential Nutrition Pack

Pain & Inflammation  Pain & Inflammation DeFlame Nutrition Pack Disc Support - Nutra Disc® Pro-Enz™ Zymain Salizain™ Pain Recovery Pack® Clinical Magnesium

Brain Support  Brain Support Cognagen

Sleep Support  Sleep Support Lunora

Weight Management  Weight Management Probiotic Complete

Joint Health  Joint Health B6-Plus Glucosamine Chondroitin Glucosamine Chondroitin MSM Glucosamine Sulfate Glucosamine Vegetarian Joint Maintenance Joint Support Formula Nutra Disc®

Bone Health  Bone Health Bone Support Formula ® Chewable Calcium with Boron Osteo-Plex ® Nutra Cal 1:1 Osatate ® D 1,000 IU D3 Mega D D 2,000 IU D3 Ultra K2-D3 D 5,000 IU D3 Clinical D3

Multi-Vitamins  Multi-Vitamins AVED-EZE Multi Vitamin AVED-Multi Softgel AVED-Multi ® AVED-Multi ® Iron Free AVED-Kids Multivitamin Essential Nutrition Pack AVED-Prenatal Multivitamin PMS Multivitamin

Antioxidants  Antioxidants Acetyl L-Carnitine ALA - Vital ALA 300 mg Clinical Antioxidant Complex Biomax C CoQ10 E 400 I.U. Pycnogenol® T.R.I.-C-500 Ubiquinol Prime

Women’s Health  Women’s Health Prenatal Multi - AVED Prenatal Cran-Max Cranberry Iodine from Kelp (Natural Iodine) Iron Chelate Menopause Support Formula Osteo-Plex ® PMS Multivitamin T.R.I.-IRON Complex

Cardio Health  Cardio Health CoQ10 Ubiquinol Prime Garlic High Allicin Niacin Hex (No Flush) Policosanol Microtabs Red Yeast Rice

Children’s Health  Children’s Health Kids Chewable Cee Kids Chewable Multi - AVED-Kids Kids Chewable Omega-3 Pearls

Focused Formulations  Focused Formulations B12-Plus Cal-M Chromease™ Koratate Milk Thistle MSM Neuro-Ease® Prostana Saw Palmetto T.R.I. - Adrenopan T.R.I.- B-Plex Val Rest Vasotate Vitamin A 10,000 IU Zinotate

Enzymes & Digestion  Enzymes & Digestion Digest-A-Mint Digestive Complete Multi-Enzyme Probiotic Complete Fiber (Clinical Fiber) Tabs Probiotic 20 Plus

Immune Support  Immune Support L-Lysine Thymunose Ultra Seasonal Protector Zinc Lozenge, Orange

Aminos, Proteins & Essential Fats  Aminos, Proteins & Essential Fats Complete Omega Complex™ Clinical Omega-3 Flax Seed Oil Kids Chewable Omega-3 Pearls L-Glutamine

Pillows  Pillows Lumbar Cushion

Supports  Supports Neck-Cervical Collars Back-Softex Dual Adjustable Back-Permatex Dual-Adjustable Back-Universal Trochanter Belt Back-Preventative Back Support Back-Power Lifter 5000 Industrial Elbow-Terra-Prene™ Strap Wrist-Elastic Wrist Strap

Product Information & Patient Materials

Kids Chewable Omega-3 Pearls Label

Kids Chewable Omega-3 Pearls Fact Sheet

Fish Oil Supplementation Product Card

Research

Foran SE et al. Measurement of mercury levels in concentrated over-the-counter fish oil preparations: Is fish oil healthier than fish? Arch Pathol Lab Med. 2003;127:1603-05.   There is very little mercury found in fish oil supplements. All fish oil goes through a purification process prior to packaging as a supplement. These authors conclude that we likely get less mercury from fish oil compared to fish.

Harris WS. Fish oil supplementation: evidence for health benefits. Cleve Clin J Med. 2004;71(3):208-21.   This is an excellent article on the clinical utility and safety of fish oil supplements. Dr. Harris also explains that there is essentially no mercury or other pollutants in fish oil. He also explains that triglyceride and ethyl ester forms of omega-3s are equally absorbed. This paper includes tables of values for omega-3 fatty acids found in fish, fish oil, and seeds/nuts/legumes.

Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med. 2008;233:674-88.   Dr. Simopoulos has been writing about the importance of omega-3 fatty acids for many years. This is one of her latest review articles on the health benefits of omega-3s.

Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006;83(suppl):1505S–19S.   This is a detailed review article about how dietary polyunsaturated fatty acids influence inflammation and the subsequent promotion or reduction of disease expression.

Deckelbaum RJ et al. n-3 fatty acids and gene expression. Am J Clin Nutr 2006;83(suppl):1520S-25S.   Omega-3 fatty acids influence gene expression to augment the expression of health. Some of the mechanisms include direct interactions in changing the composition of cell membranes and membrane function, activating or suppressing signaling molecules, interacting directly with DNA as well as with proteins that affect the processing of transcription factors, and affecting enzyme activities and vesicular endoplasmic reticulum–Golgi trafficking.

Carpentier YA et al. n-3 fatty acids and the metabolic syndrome. Am J Clin Nutr 2006;83(suppl):1499S-504S.   The metabolic syndrome X is a well-documented pro-inflammatory state. Anti-inflammatory omega-3 fatty acids can influence various aspects of the metabolic syndrome such as by reducing insulin resistance, modestly increasing HDL cholesterol, reducing triglycerides, improving endothelial function, and improving the overall inflammatory and antioxidant status.